Sole Translocation (6;9)(p23;q34) in AML-ETO Negative AML-M2 Patient
نویسندگان
چکیده
منابع مشابه
[Acute myeloid leukemia (aml) subtype M2 with variation of the t (8;21)translocation and AML1/ETO expression].
145 bandeo GTG se detectó el caso de un varón de 36 años de edad que presentó una variante de la translocación t(8;21). Los exámenes hematológicos y análisis de inmunofenotipo del paciente fueron compatibles con una LMA subtipo M2. La variante cromosómica consistió en la translocación entre los cromosomas 8 y 21 y la inversión del cromosoma 21 derivado, cuyo cariotipo fue descrito como: 46,XYqh...
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AML1, a gene on chromosome 21 encoding a transcription factor, is disrupted in the (8;21)(q22;q22) and (3;21)(q26;q22) chromosomal translocations associated with myelogenous leukemias; as a result, chimeric proteins AML1/ETO(MTG8) and AML1/Evi-1 are generated, respectively. To clarify the roles of AML1/ETO(MTG8) and AML1/Evi-1 in leukemogenesis, we investigated subcellular localization of these...
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Homeobox genes are known to be key factors in leukemogenesis. Although the TALE family homeodomain factor Meis1 has been linked to malignancy, a role for MEIS2 is less clear. Here, we demonstrate that MEIS2 is expressed at high levels in patients with AML1-ETO-positive acute myeloid leukemia and that growth of AML1-ETO-positive leukemia depends on MEIS2 expression. In mice, MEIS2 collaborates w...
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The diagnostic karyotype of acute leukemia can be used to identify biologically distinct subsets of this heterogeneous disease. Chromosome 9p rearrangement accounts for approximately 10% of adult acute lymphoblastic leukemia (ALL). However, to our knowledge, there has been no report of acute myeloid leukemia (AML) with deletion of 9p22 as the sole cytogenetic abnormality. We here describe a nov...
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AML1, a gene on chromosome 21 encoding a transcription factor, is disrupted in the (8;21)(q22;q22) and (3;21)(q26;q22) chromosomal translocations associated with myelogenous leukemias; as a result, chimeric proteins AML1/ETO(MTG8) and AML1/Evi-1 are generated, respectively. To clarify the roles of AML1/ETO(MTG8) and AML1/Evi-1 in leukemogenesis, we investigated subcellular localization of these...
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ژورنال
عنوان ژورنال: Journal of Down Syndrome & Chromosome Abnormalities
سال: 2017
ISSN: 2472-1115
DOI: 10.4172/2472-1115.1000125